Loneliness in adolescence and prescription of psychotropic drugs in adulthood: 23-year longitudinal population-based and registry study

Background The role of adolescent loneliness in adult mental health and prescriptions of psychotropic drugs remains underexplored.Aims We aim to determine whether (a) experiencing loneliness in adolescence and (b) changes in loneliness from adolescence to adulthood are prospectively associated with prescriptions for a variety of psychotropic drugs

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Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons

Functional interactions between G protein-coupled receptors are poised to enhance neuronal sensitivity to neuromodulators and therapeutic drugs.Mu and delta opioid receptors (MORs and DORs) can interact when overexpressed in the same cells, but whether co-expression of endogenous MORs and DORs in neurons leads to functional interactions is unclear.

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Sedimentary characteristics and facies model of gravity flow deposits of Late Triassic Yanchang Formation in southwestern Ordos Basin, NW China

Based on cores and logging data, and gravity flow theory, the sedimentary characteristics and facies model of gravity flow deposits in the Longdong area in southwestern Ordos Basin were analyzed.Five types of gravity flow deposits are recognized: slides, slumps, sandy debris flows, muddy debris flows and turbidity currents.Affected by multiple prov

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Heeling Moment Acting on a River Cruiser in Manoeuvring Motion

By using fully theoretical method the BIO COENZ PANTETHINE B5 heeling moment due to centrifugal forces has been determined for a small river cruiser in turning manoeuvre.The authors applied CFD software for determination of hull hydrodynamic forces, and open water characteristics of ducted propeller for estimation of thrust of CUTTING SHEARS rudder

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